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目的 探讨脑梗死患者脑脊液 (CSF)中白细胞介素 6 (IL 6 )的水平及临床价值。方法 采用酶联免疫吸附双抗体夹心 (ELISA)法 ,检测 2 0例脑梗死患者及 10例对照组CSF中IL 6的水平 ,并进行动态观察。结果 脑梗死患者各时间点的CSF中IL 6的水平 ,显著高于正常对照组 ,3天内达高峰 ,发病初CSF中IL 6的水平与 3个月后的脑损伤容积明显相关 (r =0 .6 3,P <0 .0 5 )。结论 脑梗死患者CSF中IL 6的水平的测定 ,可作为判断脑损伤程度的一项早期指标。
Objective To investigate the level and clinical value of interleukin 6 (IL 6) in cerebrospinal fluid (CSF) of patients with cerebral infarction. Methods The level of IL 6 in CSF of 20 cerebral infarction patients and 10 control subjects was detected by enzyme-linked immunosorbent assay (ELISA). Results The level of IL-6 in CSF at each time point was significantly higher in patients with cerebral infarction than in the control group and peaked within 3 days. The level of IL-6 in the CSF at the onset of onset was significantly correlated with the volume of brain injury after 3 months (r = 0 .6 3, P <0. 05). Conclusion The determination of IL 6 levels in CSF of patients with cerebral infarction can be used as an early indicator to judge the extent of brain injury.