狼疮性肾炎是系统性红斑狼疮常见的并发症,传统的治疗以环磷酰胺和糖皮质类固醇激素为主,但部分患者反应不佳及其毒副作用限制了环磷酰胺的应用。霉酚酸酯是近年开发出来的一种新型免疫抑制剂,多项临床试验结果表明霉酚酸酯在狼疮性肾炎的诱导和(或)维持治疗阶段均能有效及安全地控制狼疮活动,减少蛋白尿,降低血清中自身抗体滴度,改善肾脏病理等,其副作用相对较少,并且没有致突变作用。 Lupus nephritis is a common complication of systemic lupus erythematosus, the traditional treatment of cyclophosphamide and glucocorticoid-based, but some patients with poor response and its side effects limit the application of cyclophosphamide. Mycophenolate mofetil is a novel immunosuppressive agent developed in recent years. A number of clinical trials have shown that mycophenolate mofetil can effectively and safely control lupus activity during the induction and / or maintenance treatment of lupus nephritis, Proteinuria, lower serum antibody titer, improve renal pathology, the side effects are relatively small, and there is no mutagenic effect.