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目的分析新疆哈萨克族(哈族)HT高血压(HT)患者血浆抵抗素水平及其与胰岛素抵抗(IR)、血糖、血脂、血压及肥胖度指标的关系。方法以新疆哈族HT患者67例及哈族健康人60例为研究对象。均测量血压、身高、体质量、腰围(WC)及臀围,抽取空腹静脉血,检测血浆抵抗素、胰岛素(FINS)、血糖(FPG)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(Apo-A1)、载脂蛋白B(Apo-B)。计算体质量指数(BMI)、腰臀比(WHR)、体内脂肪百分比(BF%)、HOMA胰岛素抵抗指数(HOMA-IR)等进行比较。结果(1)HT组血浆抵抗素水平明显高于对照组(P<0.01)。(2)相关分析显示:在HT组中,抵抗素与年龄、收缩压(SBP)、WC、BMI、WHR、BF%、FPG、FINS、HOMA-IR、TG呈显著正相关;在对照组中,抵抗素与年龄、SBP、BMI、BF%、FPG、FINS、HOMA-IR、TG呈显著正相关。(3)回归分析显示:在HT组中,HOMA-IR、FPG和BMI是影响血浆抵抗素的独立因素;在对照组中,HOMA-IR、BMI和BF%是影响血浆抵抗素的独立因素。结论哈族HT患者血浆抵抗素浓度升高,其血浆抵抗素与肥胖、血糖及IR关系密切,与血压可能存在间接关系。
Objective To analyze the level of plasma resistin and its relationship with insulin resistance (IR), blood glucose, blood lipid, blood pressure and obesity in Xinjiang HT (HT) patients with Kazakh (Kazak) in Xinjiang Uygur Autonomous Region. Methods Sixty-six HT patients in Ha nationality and 60 healthy subjects in Ha ethnic group were studied. Blood pressure, height, body mass, waist circumference (WC) and hip circumference were measured and fasting venous blood was collected for determination of plasma resistin, insulin, FPG, TC, TG, HDL-C, LDL-C, Apo-A1 and Apo-B. Body mass index (BMI), WHR, BF%, HOMA-IR were calculated. Results (1) The level of plasma resistin in HT group was significantly higher than that in control group (P <0.01). (2) Correlation analysis showed that there was a significant positive correlation between resistin and age, systolic blood pressure (SBP), WC, BMI, WHR, BF%, FPG, FINS and HOMA-IR in the HT group There was a significant positive correlation between resistin and age, SBP, BMI, BF%, FPG, FINS, HOMA-IR and TG. (3) The regression analysis showed that in the HT group, HOMA-IR, FPG and BMI were independent factors affecting plasma resistin. In the control group, HOMA-IR, BMI and BF% were independent factors affecting plasma resistin. Conclusion The concentration of plasma resistin in Ha ethnic patients with HT is increased. The plasma resistin is closely related to obesity, blood glucose and IR, and may be indirectly related to blood pressure.