血液灌流(Hem operfus ion,HP)在急性药物、毒物中毒等的救治中发挥着肯定的疗效。随着HP在临床中的广泛应用,其使用过程中抗凝不足所导致的管路堵塞、不能回血、失血及灌流器凝血后吸附功能明显下降等常有发生;而过度抗凝又易致出血。因此,不论是应用普通肝素还是低分子肝素, Blood perfusion (Hem operfus ion, HP) plays a positive role in the treatment of acute drug and poison poisoning. With the extensive use of HP in clinical practice, the use of anticoagulants in the course of the lack of blockage caused by blood can not return to the blood, blood loss and blood coagulation after perfusion function decreased significantly, such as coagulation often occur; and excessive anticoagulation and easy to cause bleeding . Therefore, whether it is unfractionated heparin or low molecular weight heparin,