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妊娠期弥漫性血管内凝血(DIC)是病理妊娠的严重并发症,常与产科出血、重度子痫前期及子痫、羊水栓塞、妊娠期急性脂肪肝和感染等相关。出血、高血压和感染等可启动瀑布式病理生理反应,即全身炎症反应综合征(SIRS),致使孕产妇全身低灌注、低血流,最终导致多器官功能障碍综合征(MODS)、DIC的发生。只有尽早明确病因,评估母胎血流动力学的继发改变,及时正确地在治疗窗处理凝血功能障碍,纠正低容量、低血供和低灌注,维持血流动力学稳定,才能降低孕产妇的病死率。
Diffuse intravascular coagulation during pregnancy (DIC) is a serious complication of pathological pregnancy, often associated with obstetric hemorrhage, severe preeclampsia and eclampsia, amniotic fluid embolism, acute fatty liver during pregnancy and infection. Bleeding, high blood pressure and infection can initiate cascade pathophysiological reactions, systemic inflammatory response syndrome (SIRS), causing maternal hypoperfusion and hypoperfusion, eventually leading to multiple organ dysfunction syndrome (MODS), DIC occur. Only as soon as possible a clear etiology, to assess the secondary changes in maternal hemodynamics, timely and correct treatment of coagulation disorders in the window, correct low volume, low blood supply and low perfusion and maintain hemodynamic stability in order to reduce maternal Case fatality rate.