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本文选择胃癌、胃良性病变、尸检胎儿及足月新生儿的胃标本,分别作粘液组化。M—E染色,并应用光镜和电镜进行对照观察。胃癌异质性表现在同一病例有多种组织学类型;癌组织出现多种类型粘液;癌细胞形态不一,胞浆内可见各种不同类型的分泌颗粒、酶原颗粒、内分泌颗粒、粘液颗粒;粘液颗粒还可通过不同方式向外排出;所有胃癌病例均可见多寡不等含微丝束之微绒毛等。我们通过胎儿胃上皮演变过程的对比观察,发现各种类型胃上皮均来自未成熟的粘液细胞,相当于成人的胃颈粘液细胞。胃癌亦是源发于颈粘液细胞,肠型胃癌的发生也不一定必须经历肠上皮化生的中间阶段。
This article selects stomach specimens for gastric cancer, benign gastric lesions, autopsied fetuses, and full-term neonates for mucus histochemistry. M-E staining and light and electron microscopy were used for control observation. The heterogeneity of gastric cancer has multiple histological types in the same case; multiple types of mucin are present in the cancerous tissue; the cancer cells have different shapes, and various types of secretory granules, zymogen granules, endocrine granules, and mucus granules are seen in the cytoplasm. Mucus particles can also be discharged in different ways; all gastric cancer cases can be seen in microvilli containing microfilaments. Through comparative observations of the evolution of fetal stomach epithelium, we found that all types of gastric epithelium were derived from immature mucinous cells, equivalent to adult gastric-neck mucous cells. Gastric cancer is also originated in cervical mucous cells. The occurrence of intestinal type gastric cancer does not necessarily have to go through the intermediate stages of intestinal metaplasia.