目的:研究胎盘早剥患者血清中CA125的水平,探讨胎盘早剥的早期诊断依据。方法:选取胎盘早剥患者52例作为试验组,正常妊娠孕妇40例为对照组,检测孕妇血清中CA125的水平。结果:试验组血清CA125≥39 U/ml 43例,均值为66.7 U/ml;对照组血清CA125≥39 U/ml 2例,均值为20.7 U/ml,两组差异有统计学意义(P<0.05)。血清CA125预测胎盘早剥发生的敏感性为90.3%,特异性为95.0%。结论:孕妇血清中CA125、PLGF的检测值可以作为胎盘早剥早期诊断的指标之一。 Objective: To study the serum levels of CA125 in patients with placental abruption and to explore the basis of early diagnosis of placental abruption. Methods: Totally 52 cases of placental abruption were selected as experimental group and 40 normal pregnant women as control group. The serum levels of CA125 in pregnant women were detected. Results: The serum CA125≥39 U / ml in the test group was 43 cases (mean 66.7 U / ml). The serum CA125≥39 U / ml in the control group was 2 cases (mean 20.7 U / ml), with significant difference between the two groups (P < 0.05). The sensitivity of serum CA125 in predicting the occurrence of placental abruption was 90.3% and the specificity was 95.0%. Conclusion: The serum levels of CA125 and PLGF in pregnant women can be used as one of the indicators of early diagnosis of placental abruption.