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目的:观察西宁地区前列腺素E1(PGE1)治疗结缔组织病合并肺动脉高压(PAH)的疗效。方法:选择2003年10月—2005年11月住院患者中确诊为弥漫性结缔组织病合并PAH 13例。给予静脉用PGE1,14天为一个疗程。观察治疗前、治疗后6分钟步行距离、静息状态下平均肺动脉压(mPAP)、动脉血氧分压(PO2)、动脉血二氧化碳分压(PCO2)、血氧饱和度(SO2)、心脏指数(CI)指标的变化。结果:经PGE1治疗14天后,测定6分钟步行距离、mPAP、PO2、PCO2、SO2、CI均较治疗前有显著改善(P<0.05)。结论:PGE1能够降低结缔组织病所致的肺动脉高压,改善心肺功能,提高运动耐力。
Objective: To observe the efficacy of prostaglandin E1 (PGE1) in treatment of connective tissue disease complicated pulmonary hypertension (PAH) in Xining area. Methods: Thirteen patients diagnosed as diffuse connective tissue disease complicated with PAH from October 2003 to November 2005 were selected. Give intravenous PGE1 for 14 days for a course of treatment. Observed before treatment, walking distance 6 minutes after treatment, resting mean pulmonary arterial pressure (mPAP), arterial oxygen pressure (PO2), arterial partial pressure of carbon dioxide (PCO2), oxygen saturation (SO2), cardiac index (CI) indicators of change. Results: After 14 days treatment with PGE1, mPAP, PO2, PCO2, SO2 and CI were all significantly improved (P <0.05). Conclusion: PGE1 can reduce pulmonary hypertension induced by connective tissue disease, improve cardiopulmonary function and improve exercise endurance.