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目的:观察隔药灸对胃癌化疗期间骨髓抑制的临床疗效。方法:将72例胃癌患者随机分为治疗组35例和对照组37例,两组均予SOX方案化疗,治疗组化疗当天联用隔药灸,连用14 d,休息7 d,21 d为1个周期。2个周期后观察患者化疗后第3、7、14 d骨髓抑制情况,化疗后伴随症状评分及疗效及KPS评分。结果:两组患者的WBC、NEUT在治疗第3、7均较治疗前下降,治疗组的WBC显著高于对照组(P<0.05或P<0.01),治疗组第7 d的NEUT显著高于对照组(P<0.01);治疗第14 d,两组患者的WBC、NEUT均有升高趋势,治疗组WBC的升高程度由于对照组(P<0.05)。化疗后第3、7、14 d治疗组各分级骨髓抑制例数均显著少于对照组(P<0.05);治疗组化疗后第14 d各分级骨髓抑制例数显著少于第3 d骨髓抑制的患者例数(P<0.05)。化疗后14 d治疗组乏力、头晕及食欲减退改善均明显优于对照组(P<0.05或P<0.01)。治疗组KPS评分明显优于对照组(P<0.05)。结论:隔药灸可有效缓解化疗导致的骨髓抑制,在一定程度上缓解临床伴随症状,提高患者生活质量。
Objective: To observe the clinical curative effect of drug moxibustion on myelosuppression during gastric cancer chemotherapy. Methods: Seventy-two patients with gastric cancer were randomly divided into treatment group (n = 35) and control group (n = 37). Both groups were treated with SOX regimen. The treatment group was treated with drug moxibustion on the day of chemotherapy, A cycle. After 2 cycles, the bone marrow suppression on the 3rd, 7th and 14th day after chemotherapy was observed. The symptom score, curative effect and KPS score after chemotherapy were observed. Results: The WBC and NEUT in both groups decreased at the 3rd and 7th treatment, the WBC in the treatment group was significantly higher than that in the control group (P <0.05 or P <0.01), the NEUT on the 7th day in the treatment group was significantly higher than that of the control group (P <0.01). On the 14th day after treatment, the WBC and NEUT in both groups increased. The level of WBC in the treatment group was higher than that in the control group (P <0.05). The number of myelosuppression in each treatment group was significantly less than that of the control group on the 3rd, 7th, 14th day after chemotherapy (P <0.05). The number of myelosuppression on the 14th day after chemotherapy in the treatment group was significantly less than that on the 3rd day Of patients (P <0.05). The fatigue, dizziness and loss of appetite of the 14-day treatment group were significantly better than those of the control group (P <0.05 or P <0.01). The treatment group KPS score was significantly better than the control group (P <0.05). Conclusion: Moxibustion moxibustion can effectively alleviate the bone marrow suppression induced by chemotherapy, to a certain extent, alleviate the clinical accompanying symptoms and improve the quality of life of patients.