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目的探讨基质金属蛋白酶-2(MMP-2),组织金属蛋白酶抑制剂-2(TIMP-2)在食管鳞癌中的表达及其临床意义。方法用酶谱分析法和Western blot法分别检测41例食管鳞癌患者的癌及相应正常组织中MMP-2和TIMP-2的表达变化。结果食管鳞癌组织中MMP-2的表达量升高且显著高于TIMP-2。结论MMP-2与食管鳞癌的侵袭转移有关,其机制可能与食管鳞癌组织中的MMP-2/TIMP-2平衡失调有关;MMP-2与TIMP-2联合检测有助于食管鳞癌生物学行为的判断。
Objective To investigate the expression and clinical significance of matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) in esophageal squamous cell carcinoma. Methods The expression of MMP-2 and TIMP-2 in 41 cases of esophageal squamous cell carcinoma and their corresponding normal tissues were detected by zymography and Western blot. Results The expression of MMP-2 in esophageal squamous cell carcinoma increased and was significantly higher than that of TIMP-2. Conclusion MMP-2 may be involved in the invasion and metastasis of esophageal squamous cell carcinoma. The mechanism may be related to the imbalance of MMP-2/TIMP-2 in esophageal squamous cell carcinoma. Combined detection of MMP-2 and TIMP-2 may contribute to esophageal squamous cell carcinoma Learn behavioral judgments.