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目的 :研究氧氟沙星联用抗结核药的肝毒性并探讨其机制。方法 :分别测定异烟肼组、利福平组、异烟肼利福平联合用药 (IR)组及其联用氧氟沙星 (IRO)组小鼠的血清谷氨酸氨基转移酶 (ALT)、肝指数、肝匀浆丙二醛(MDA)含量、肝微粒体细胞色素p45 0和线粒线Ca2 + ATP酶活性 ,及肝病理检查 ,结果与对照组以及实验组之间进行比较。结果 :与正常对照组及单用异烟肼、利福平组比较 ,IR组及IRO组的血清ALT、肝细胞匀浆MDA明显增高 (P <0 0 5 ) ;同时发现IR组和IRO组的肝微粒体细胞色素p45 0含量较高和线粒体Ca2 + ATP酶活性较低 ;病理检查IRO和IRC组肝细胞坏死程度稍轻但与IR组比较无明显差异。结论 :异烟肼和利福平联用氧氟沙星肝毒性增加 ,但并不比异烟肼和利福平联合时强。
Objective: To study the hepatotoxicity of ofloxacin and antituberculosis drugs and to explore its mechanism. Methods: The levels of serum glutamate aminotransferase (ALT) in isoniazid, rifampicin, isoniazid and rifampicin combined with IR group and Iloloxacin group ), Liver index, liver homogenate malondialdehyde (MDA) content, hepatic microsomal cytochrome P450 and mitochondrial Ca2 + ATPase activity, and liver pathological examination. The results were compared with the control group and the experimental group. Results: Compared with the normal control group and isoniazid and rifampicin alone group, serum ALT and hepatocyte homogenate MDA in IR group and IRO group were significantly increased (P <0.05); IR group and IRO group Of liver microsomal cytochrome p45 0 content and mitochondrial Ca2 + ATPase activity lower; pathological examination IRO and IRC group of liver cell necrosis slightly lighter but no significant difference compared with the IR group. Conclusion: Isoniazid and rifampicin combined with ofloxacin hepatotoxicity increased, but not when combined with isoniazid and rifampicin strong.