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１００只２．５月龄清洁级ＳＤ雄性大鼠分为３组：Ａ组４５只，Ｂ组２２只，Ｃ组３３只。Ａ组大鼠膀胱内注入血清８型溶脲脲原体菌株Ｔ９６０；Ｂ组除与Ａ组同样处理外，且在接种后３个月给予美满霉素（２０～１００ｍｇ／ｋｇ），连续１４ｄ；Ｃ组为对照组，每只动物给予等量溶脲脲原体液体培养基。结果：Ａ组８７．５％、Ｂ组２０％的动物膀胱组织的溶脲脲原体培养阳性，Ｃ组为阴性；Ａ、Ｂ两组有极显著差异（Ｐ＜０．００１），表明美满霉素能有效地抑制溶脲脲原体。Ａ组膀胱结石检出率为４０％，Ｂ组为３５％，Ｃ组为零；Ａ、Ｂ两组无明显差异（Ｐ＞０．１）。
100 male 2.5-month-old clean SD male rats were divided into 3 groups: A group of 45, B group 22, C group 33. A group of rats were injected intravesical inoculation of serotype 8 Ureaplasma urealyticum strain T960; group B was treated with minocycline (20-100 mg / kg) 3 months after vaccination except for the same treatment as group A for 14 days; Group C as control group, each animal was given the same amount of liquid urease of Ureaplasma urealyticum. Results: A group of 87.5%, B group 20% of animal bladder tissue of Ureaplasma urealyticum culture positive, C group was negative; A, B two groups were significantly different (P <0.001), indicating that the Mycophenolate can effectively inhibit ureaplasma urealyticum. The detection rate of bladder stones in group A was 40%, in group B was 35%, and in group C was zero. There was no significant difference between group A and group B (P> 0.1).