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目前多数学者认为子痫前期发病的根本原因是滋养细胞浸润能力受损,子宫螺旋动脉重铸障碍,致胎盘浅着床。由于功能异常的胎盘释放到母体循环中的一些因子所引起,如氧诱导因子1α、血管生长因子、胎盘生长因子、可溶性血管生长因子受体-1、神经激肽B、合体滋养细胞层微绒毛膜等,其相关因子的表达及含量异常,在子痫前期的发生、形成、发展中起关键作用,研究这些因子有助于子痫前期疾病的研究、预防及治疗。
At present, most scholars believe that the fundamental cause of preeclampsia is impaired trophoblastic infiltration, uterine spiral artery recanalization disorder, causing the placenta asymptomatic. Due to the release of dysfunctional placenta into the maternal circulation, several factors such as oxygen-induced factor 1α, vascular growth factor, placental growth factor, soluble vascular growth factor receptor-1, neurokinin B, syncytiotrophoblastic microvilli Membrane, the expression of related factors and the abnormal content play an important role in the occurrence, formation and development of preeclampsia, and the study of these factors contribute to the research, prevention and treatment of preeclampsia.