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本文报道我们应用氮分子激光器和汞灯作为光源,诱发肿瘤组织产生固有荧光的方法和观察结果。本组共观察临床病人25例和手术切除标本14个。用上述光源辐照病人的肿瘤部位时,有20例局部产生桔红色荧光,再取活组织检查,均证实为恶性肿瘤,用专用的检测系统检测、记录其特征峰,峰值为6000～G200。而另5例局部辐照时产生蓝白色光,其峰值为4600～4800,活检诊断为良性肿瘤或慢性炎症。手术标本检测情况与临床病人相似。上述结果表明,癌肿组织经一定的光源激发后产生固有的特征光谱,发出桔红色荧光,与良性肿瘤和慢性炎症有所区别。本研究为恶性肿瘤的早期诊断提供了一个新的方法。本文并对荧光产生的机理,恶性肿瘤固有荧光观察法的优点和光源等问题进行了讨论。
In this paper, we report the methods and observations of the use of nitrogen molecular lasers and mercury lamps as light sources to induce intrinsic fluorescence in tumor tissue. A total of 25 clinical patients and 14 surgical specimens were observed in this group. When the above-mentioned light source was used to irradiate the tumor site of the patient, there were 20 cases with orange-red fluorescence, and then biopsy. All of these were confirmed as malignant tumors, and their characteristic peaks were detected and recorded with a dedicated detection system. The peak value was 6000-G200. In the other 5 cases, blue-white light was generated during local irradiation, and the peak value was 4600-4800. Biopsy was diagnosed as benign tumor or chronic inflammation. Surgical specimen detection is similar to that of clinical patients. The above results showed that the cancer tissue generated after excitation by a certain light source had an inherent characteristic spectrum and emitted orange-red fluorescence, which was different from benign tumor and chronic inflammation. This study provides a new method for the early diagnosis of malignant tumors. This paper discusses the mechanism of fluorescence generation, the advantages of intrinsic fluorescence observation of malignant tumors, and the issue of light sources.