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Oxiconazole (4a),a new broad-spectrum antifungal agent,was synthesizedaccording to the method reported by Mixich G et al and some improvement was made in thepreparation of N-(2,4-dichlorobenzoylmethyl) imidazole (2),an important intermediate.Inan effort to search for more effective antifungal drugs by chemical modification,severalimidazolyl oxime ether derivatives were synthesized.The structures of the syntheticproducts were proved by elemental analysis.In vitro fungistatic tests showed thatcompounds 4a-g and 7 were more effective than clotrimazole against most of the fungalstrains tested and that compound 4c possessed antifungal action against Aspergillus whileothers including oxiconazole didn’t.The structure of compound 4a (oxiconazole) wasconfirmed by UV,IR,~1H-NMR and MS.
Oxiconazole (4a), a new broad-spectrum antifungal agent, was synthesizedaccording to the method reported by Mixich G et al and some improvement was made in the preparation of N- (2,4-dichlorobenzoylmethyl) imidazole (2), an important intermediate. Inan effort to search for more effective antifungal drugs by chemical modification, severalimidazolyl oxime ether derivatives were synthesized.The structures of the synthetic products were proved by elemental analysis. In vitro fungistatic tests showed thatcompounds 4a-g and 7 were more effective than clotrimazole against most of the fungalstrains tested and that compound 4c possessed antifungal action against Aspergillus while the house containing oxiconazole didn’t.The structure of compound 4a (oxiconazole) wasconfirmed by UV, IR, ~ 1H-NMR and MS.