以稻草为原料,FeCl_3为催化剂,在甲苯/水双相溶剂体系中高压液化制备糠醛,所得糠醛废液中含有大量的5-羟甲基糠醛。以氯乙酸为催化剂,利用糠醛废液进一步催化制备乙酰丙酸。通过响应面法研究了催化剂质量分数、反应温度、反应时间对乙酰丙酸收率的影响,得出乙酰丙酸收率的二次回归方程。通过响应面分析及实验验证得到糠醛废液制备乙酰丙酸的最佳条件为:催化剂质量分数为10%,反应温度为198℃,反应时间为50 min,乙酰丙酸收率高达54.24%。 Using straw as raw material and FeCl_3 as catalyst, furfural was prepared by high pressure liquefaction in a toluene / water two-phase solvent system. The resulting wastewater containing furfural contained a large amount of 5-hydroxymethylfurfural. Using chloroacetic acid as catalyst, the levulinic acid was further catalyzed by using furfural waste liquid. The influence of catalyst mass fraction, reaction temperature and reaction time on the yield of levulinic acid was studied by response surface methodology. The regression equation of levulinic acid yield was obtained. The optimum conditions for the preparation of levulinic acid from waste liquid of furfural by response surface analysis and experimental verification are as follows: the mass fraction of catalyst is 10%, the reaction temperature is 198 ℃, the reaction time is 50 min, and the yield of levulinic acid is up to 54.24%.