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目的观察纳络酮联合复方丹参治疗新生儿缺氧缺血性脑病(HIE)的疗效。方法将74例HIE患者随机分为两组,对照组36例采用镇静、止惊、降颅压、纠正酸碱失衡及代谢紊乱、脑代谢激活剂等治疗,治疗组38例在上述治疗基础上联合应用纳络酮、复方丹参静脉滴注。结果治疗组的有效率94.7%,明显优于对照组的75.0%,两组差异有统计学意义(P<0.05)。结论纳络酮联合复方丹参治疗HIE,疗效好,病程短,值得临床推。
Objective To observe the curative effect of naloxone combined with compound Salvia miltiorrhiza on neonatal hypoxic-ischemic encephalopathy (HIE). Methods Seventy-four patients with HIE were randomly divided into two groups. The control group (36 patients) was treated with sedation, stopping shock, reducing intracranial pressure, correcting acid-base imbalance and metabolic disorders, and activating brain metabolism. Based on the above treatment Combination of naloxone, compound Salvia intravenous drip. Results The effective rate of the treatment group was 94.7%, which was significantly better than that of the control group (75.0%). The difference between the two groups was statistically significant (P <0.05). Conclusion Naloxone combined with compound Danshen treatment of HIE, good curative effect, short course, worthy of clinical push.