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目的观察免疫疗法(胸腺五肽与乙肝疫苗)联合苦参素治疗慢性乙型肝炎的疗效。方法慢性乙型肝炎86例,分成治疗组43例和对照组43例。治疗组给予胸腺五肽与乙肝疫苗联合苦参素药物治疗6个月;对照组仅给予苦参素药物治疗6个月。结果治疗组HBeAg及HBV DNA转阴率分别为48.8%和69.8%;对照组分别为23.3%和41.9%,两组差异有统计学意义(P<0.05)。结论胸腺五肽与乙肝疫苗联合苦参素治疗慢性乙型肝炎有一定的疗效。
Objective To observe the curative effect of immunotherapy (thymopentin and hepatitis B vaccine) combined with oxymatrine on chronic hepatitis B (CHB). Methods Chronic hepatitis B (86 cases) was divided into treatment group (43 cases) and control group (43 cases). The treatment group was given thymopentin and hepatitis B vaccine combined with matrine drug treatment for 6 months; the control group was given only matrine drug treatment for 6 months. Results The negative rates of HBeAg and HBV DNA in the treatment group were 48.8% and 69.8% respectively, while those in the control group were 23.3% and 41.9% respectively. There was significant difference between the two groups (P <0.05). Conclusion Thymopentin and hepatitis B vaccine combined with matrine in the treatment of chronic hepatitis B has a certain effect.