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结肠直肠癌(colorectal cancer,CRC)是威胁人类健康和生命的常见恶性肿瘤,其发病率和病死率均居恶性肿瘤前列。治疗失败继而导致死亡的主要原因为复发和转移[1]。传统认为,脑转移是CRC的终末期改变,发生率较低,但预后极差,往往在脑转移前病人已死于其他部位的转移,故临床上不受重视[2]。近年,转移性CRC的总体预后,尤其是肝转移及肺转移的预后明显改善[3-4]。治疗手段的进步及综
Colorectal cancer (CRC) is a common malignant tumor that is a threat to human health and life. Its morbidity and mortality rate rank forefront of malignant tumors. The main cause of treatment failure resulting in death is recurrence and metastasis [1]. Traditionally, brain metastasis is the end of the CRC changes, the incidence is low, but the prognosis is poor, often in patients with brain metastases before the patient died of metastases elsewhere, so clinically neglected [2]. In recent years, the overall prognosis of metastatic CRC, especially the prognosis of liver metastases and lung metastases has been significantly improved [3-4]. Progress and comprehensive treatment