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目的:研究慢性房颤(AF)患者血清中心房利钠肽(ANP)和脑利钠肽(BNP)水平的变化及其临床意义。方法:采用放射免疫方法测定98例有AF的心脏疾病患者(AF组)、40例无AF的心脏疾病患者(无AF组)和30例健康对照者(对照组)血清ANP和BNP水平,并进行统计分析。结果:AF组血清ANP和BNP水平均显著高于无AF组和对照组(P均<0.01);无AF组血清BNP水平显著高于对照组(P<0.01),但血清ANP水平与对照组无显著差异(P>0.05);AF组血清ANP水平与BNP水平呈显著正相关(P<0.01),而且AF组患者血清ANP和BNP水平随心功能分级的提高而显著递增(P<0.01)。结论:AF患者血清ANP和BNP水平显著增高,并随心功能分级依次递增。
Objective: To investigate the changes of serum levels of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in patients with chronic atrial fibrillation (AF) and its clinical significance. Methods: Serum ANP and BNP levels in 98 patients with AF (AF group), 40 AF patients without heart disease (AF group) and 30 healthy controls (control group) were determined by radioimmunoassay conduct statistical analysis. Results: Serum levels of ANP and BNP in AF group were significantly higher than those in non-AF group and control group (all P <0.01). Serum BNP levels in AF group were significantly higher than those in control group (P <0.01) (P <0.05). There was a significant positive correlation between serum ANP level and BNP level in AF group (P <0.01). The levels of ANP and BNP in AF group increased significantly with the increase of cardiac function (P <0.01). Conclusion: The levels of serum ANP and BNP in patients with AF are significantly higher than those in patients with AF.