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目的分析恶性肿瘤患者化疗诱发糖尿病的机理,提醒临床医师重视化疗患者血糖的检测。方法回顾我院肿瘤科1998年7月至2005年7月住院化疗患者1689例病历资料,进行归纳、分析。结果有12例恶性肿瘤患者化疗诱发糖尿病,占同期我科住院化疗患者总人数的0.71%,其中第3次化疗后发生糖尿病4例,第5次化疗后发生5例,第7次化疗后发生2例,第11次化疗后发生1例。停止化疗后无1例自行缓解。有5例肿瘤控制后一直使用降糖药物,4例死于肿瘤复发转移,3例死于感染。结论恶性肿瘤患者化疗可诱发糖尿病,其临床表现有时不典型,临床医师应留心患者的血糖变化。
Objective To analyze the mechanism of chemotherapy-induced diabetes in patients with malignant tumors and to remind clinicians to attach importance to the detection of blood glucose in patients undergoing chemotherapy. Methods The data of 1689 cases of inpatients with chemotherapy in our hospital from July 1998 to July 2005 were retrospectively analyzed and summarized. Results 12 patients with malignant tumor chemotherapy-induced diabetes mellitus, accounting for 0.71% of the total number of patients in our department in the same period of chemotherapy, including diabetes after the third chemotherapy in 4 cases, 5 after chemotherapy occurred in 5 cases, after the 7th chemotherapy occurred 2 cases, 1 case occurred after the 11th chemotherapy. No case of spontaneous remission after chemotherapy. There are 5 cases of cancer control has been using hypoglycemic drugs, 4 patients died of tumor recurrence and metastasis, 3 patients died of infection. Conclusion Chemotherapy in patients with malignant tumors can induce diabetes, and its clinical manifestations are sometimes atypical. Clinicians should pay attention to the changes of blood glucose in patients.