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一是肠溶制剂这类药剂要求药性到了肠道才释放出来,一旦药物被分割后,肠溶衣就被破坏了,失去了肠溶衣的保护,片心药物在胃中就会释放出来。如果是多酶片等助消化药,就会被胃酸破坏而失去疗效;如果是红霉素肠溶片、阿斯匹林肠溶片,因片心药物的提前释放会损伤胃黏膜,引起口腔溃疡和食管炎。二是控释缓释制剂这类药物应在体内逐渐地慢慢释放出来,以连续补充体内的药量。缓释片是用特殊的高硬度材料做成骨架,药物包藏于骨架中缓慢释放。若研碎则会破坏骨架,影响药效,还会引起副作用。所以,
First, enteric preparations of such agents require the release of the drug to the gut, once the drug is divided, the enteric coating is destroyed, lost the protection of enteric coating, tablets drug will be released in the stomach. If it is more enzyme tablets and other digestive drugs, it will be destroyed by the stomach acid and lose efficacy; if it is erythromycin enteric-coated tablets, aspirin enteric-coated tablets, due to the early release of ephedrine drugs can damage the gastric mucosa, causing the mouth Ulcers and esophagitis. Second, controlled-release sustained-release preparations of these drugs should be slowly gradually released in the body to continuously supplement the body’s dose. Sustained release tablets are made of a special high hardness of the skeleton, the drug contained in the framework of the slow release. If broken will destroy the skeleton, affect the efficacy, but also cause side effects. and so,