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近年来大量研究发现,小分子核糖核酸(microRNA,miRNA)是一个庞大的小分子调控RNA家族,是约22个核苷酸的单链非编码小分子RNA,在转录后水平调节基因的表达。目前人类基因组已鉴定的miRNA超过2000种,参与了近1/3基因的表达调控~([1])。研究发现,miRNA不仅在发育调控~([2])、细胞增殖~([3])和死亡、造血过程~([4])等方面发挥着重要的作用,也对肾脏发育、肾细胞癌、肾小球疾病、糖尿病肾病、肾间
In recent years, a large number of studies have found that small miRNAs (miRNAs) are large, small-molecule regulatory RNAs and are about 22-nucleotide single-stranded non-coding small RNAs that regulate gene expression at post-transcriptional level. At present, more than 2,000 miRNAs have been identified in the human genome, involving in the regulation of nearly one third of genes (1). It has been found that miRNA plays an important role not only in the development and regulation of cell proliferation and death, but also in the development of hematopoietic cells [4], renal cell carcinoma , Glomerular disease, diabetic nephropathy, and renal