先兆性血栓病的预治,我科常用藻酸双酯钠(P.S.S.)片口服,也使用P.S.S.针剂静滴,一年来共治200多例,其中3例过敏反应,报告如下: 例1 男,67岁,退休工人,发现“高血压”一年,举步困难1天入院。有磺胺过敏史,蝮蛇抗栓酶皮试阳性。入院后诊断:高血压病Ⅲ期,混合性中风。治疗:低分子右旋醣酐500ml加丹参针12ml静滴,qd,共20天。停药4天后复查血流变检查示:高凝血症。改用P.S.S.200mg加入生理盐水250ml静滴,qd,第二天静滴P.S.S.完毕后约20分钟,突然畏塞、下肢麻、颤抖,继之寒战、心慌。体检:神清,皮肤肢体凉,BP25/15kPa,心率110次/分,律齐,认为输液反应。予抗过敏处理。1小时10分钟后体检:BP22/14kPa,一般情况均恢复如用药前。例2 女,74岁,退休教师。高血压病史19年,右侧头痛,耳鸣5年。自述对药较“敏感”,无明确药物过敏史。体检:BP17.2/10.5kPa,诊断:脑动脉 Thrombosis premonitory thrombosis, our department commonly used alginate diester sodium (PSS) tablets orally, but also the use of intravenous injection of PSS injection, a total of more than 200 cases over the year, of which 3 cases of allergic reactions, the report is as follows: 1 male, 67 years old, retired workers, found “high blood pressure” a year, difficulty walking 1 day admission. Sulfonamide allergy, viper antithrombin skin test positive. Post-hospital diagnosis: Hypertension III, mixed stroke. Treatment: low molecular weight dextran 500ml plus Salvia 12ml intravenous infusion, qd, a total of 20 days. 4 days after discontinuation of blood flow examination showed: hypercoagulability. Use P.S.S200mg saline 250ml intravenous infusion, qd, the next day after intravenous infusion P.S.S. about 20 minutes after the sudden fear of plug, lower limbs Ma, trembling, followed by chills, palpitation. Physical examination: God clear, cold skin, BP25 / 15kPa, heart rate 110 beats / min, law Qi, that the infusion reaction. To anti-allergic treatment. 1 hour and 10 minutes after the physical examination: BP22 / 14kPa, the general situation were restored before treatment. Example 2 Female, 74 years old, retired teacher. Hypertension 19 years, right headache, tinnitus 5 years. Read the drug more “sensitive”, no clear history of drug allergies. Physical examination: BP17.2 / 10.5kPa, Diagnosis: Cerebral artery