论文部分内容阅读
目的:探讨结直肠癌组织中存活素(Survivin)的表达与各临床病理因素的关系,评价Survivin在结直肠癌预后判断中的价值。方法:采用免疫组织化学PowerVision两步法检测40例结直肠癌组织中Survivin的表达情况,回顾性分析Survivin与各临床病理因素及预后之间的关系。结果:Survivin在结直肠癌组织中的表达阳性率均明显高于癌旁正常组织(P<0.01),与Dukes分期及淋巴结转移有明显相关(P<0.05),DukesC期、D期结直肠癌组织明显高于DukesA期、B期,有淋巴结转移组Survivin阳性率明显高于无淋巴结转移组。Survivin阳性表达患者3年、5年生存率明显低于表达阴性者(P<0.05)。结论:在结直肠癌发生、发展过程中伴随着Survivin的表达,检测结直肠癌组织Survivin可能对判断结直肠癌的淋巴结转移及病情进展有一定的价值。Survivin阳性的患者3年、5年生存率明显降低,对其进行检测,可以对结直肠癌患者的预后评估有一定的辅助意义。
Objective: To investigate the relationship between survivin expression and clinicopathological parameters in colorectal cancer and to evaluate the value of Survivin in the prognosis of colorectal cancer. Methods: The expression of Survivin in 40 cases of colorectal cancer tissues was detected by immunohistochemistry PowerVision two-step method. The relationship between Survivin and clinicopathological factors and prognosis was analyzed retrospectively. Results: The positive rates of Survivin in colorectal cancer tissues were significantly higher than those in adjacent normal tissues (P <0.01), and were significantly correlated with Dukes stage and lymph node metastasis (P <0.05). DukesC stage and D stage colorectal cancer The positive rate of Survivin in lymph node metastasis group was significantly higher than that in Dukes A phase and B phase group, which was significantly higher than that in non-lymph node metastasis group. The 3-year and 5-year survival rates of patients with positive Survivin expression were significantly lower than those with negative expression (P <0.05). Conclusion: Survivin is associated with the occurrence and development of colorectal cancer. Detection of Survivin in colorectal cancer may be valuable in judging the lymph node metastasis and progression of colorectal cancer. Survivin positive patients 3 years, 5-year survival rate was significantly lower, its detection, can be prognostic for patients with colorectal cancer have some auxiliary significance.