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[目的]观察养肝利胆颗粒(YGLD)对豚鼠胆色素结石形成过程中炎症环节的影响。[方法]应用雄性豚鼠皮下注射林可霉素联合喂养致石饲料建立胆色素结石模型,观察YGLD对该模型成石率、胆囊容积、胆汁中黏蛋白及C反应蛋白(CRP)浓度的影响。[结果]YGLD组与模型组比较成石率显著降低(P<0.01),胆囊容积明显减小(P<0.05),胆汁中黏蛋白及CRP浓度明显降低(P<0.05)。[结论]YGLD通过降低胆汁中黏蛋白、CRP水平来发挥逆转成石胆汁及降低胆色素结石成石率的重要作用。
[Objective] To observe the effect of Yanggan Lidan Granules (YGLD) on the inflammatory aspects of guinea pig gallstone formation. [Methods] The gallstone pigment calculus model was established by subcutaneous injection of lincomycin in male guinea pigs and stone feeding. The effects of YGLD on stone formation rate, gallbladder volume, mucin and CRP concentration in bile were observed. [Results] Compared with the model group, the rate of stone formation in YGLD group was significantly lower (P<0.01), gallbladder volume was significantly decreased (P<0.05), mucin and CRP concentrations in bile were significantly decreased (P<0.05). [Conclusion] YGLD plays an important role in reversing lithogenesis bile and reducing the rate of gallstone formation by decreasing the mucin and CRP levels in bile.