不对称催化反应在手性药物合成中的作用越来越大,特别是随着小分子催化剂的广泛应用,利用与底物的结合来获得新药合成方法,将成为未来药物合成中的新趋向。本文将着重从小分子催化反应探讨入手,就其在药物合成中的应用展开研究。 Asymmetric catalytic reactions in the synthesis of chiral drugs play an increasingly important role, especially with the widespread use of small molecule catalysts, the use of combination with the substrate to obtain new drug synthesis methods, will become the new trend in the future of drug synthesis. This article will focus on the catalytic reaction of small molecules to start with, on its application in the study of drug synthesis.