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二烯丙基二硫(diallyl disulfide,DADS)具有抑制肿瘤细胞增殖,调控细胞周期依赖素激酶、信号转导,诱导肿瘤细胞分化、凋亡及影响癌基因与抑癌基因表达的作用。小剂量DADS(1·25mg·L-1)可以抑制JAK1/STAT3信号通路,将HL-60细胞阻滞在G0/G1期,诱导HL-60细胞向粒系分化,其作用与?
Diallyl disulfide (DADS) can inhibit tumor cell proliferation, regulate cell cycle dependent kinases, signal transduction, induce tumor cell differentiation, apoptosis and affect the expression of oncogenes and tumor suppressor genes. Low-dose DADS (1.25 mg · L-1) could inhibit JAK1 / STAT3 signaling pathway, arrest HL-60 cells in G0 / G1 phase and induce HL-60 cells to differentiate into granulocytes.