建立多房棘球蚴（Ｅｃｈｉｎｏｃｏｃｃｕｓｍｕｌｔｉｌｏｃｕｌａｒｉｓ，Ｅ．ｍ）感染沙鼠的过敏反应模型以了解包虫病所致过敏反应的ＩｇＥ变化规律。取长爪沙鼠６０只，用酶联免疫吸附试验测定ＩｇＥ水平。随机抽取健康沙鼠１２只测定ＩｇＥ水平作为ＩｇＥ基础值参照组；人工腹腔接种Ｅ．ｍ感染长爪沙鼠４８只，感染Ｅ．ｍ四周和三个月后各抽取１２只测定ＩｇＥ作为Ｅ．ｍ感染后ＩｇＥ水平参照组和决定性注射前ＩｇＥ水平参照组；再根据决定性注射致敏原不同，将Ｅ．ｍ感染的另外２４只长爪沙鼠分为三组，分别进行攻击发敏，建立过敏反应模型。在决定性注射致敏原后，观察症状６０ｍｉｎ再测定ＩｇＥ水平。结果为ＩｇＥ水平随Ｅ．ｍ感染沙鼠的时间推移而升高，攻击发敏前达高峰，发敏后６０ｍｉｎ明显下降。过敏反应发生率最高为１００％，最低为６２．５％，过敏性休克发生率为１２．５％。过敏反应模型症状典型，结果可靠，可应用于包虫病反致过敏性休克的系列防治实验研究中。ＩｇＥ水平变化在包虫病致过敏性休克的发生、发展中起重要作用 To establish an anaphylactic model of gerbil infected with Echinococcus multilocularis (E.m.) to understand the change of IgE in the allergic reaction induced by hydatid disease. Sixty Meriones unguiculatus mice were taken and IgE levels were determined by enzyme linked immunosorbent assay. Twelve healthy gerbils were randomly selected to determine the level of IgE as a baseline IgE reference group; M infection Mongolian gerbils 48, E. infection. Twelve samples of IgE were taken as E after four weeks and three months respectively. m after infection IgE level of reference group and the level of IgE before deciduous injection reference group; then according to the decision of the different injection of allergens, E. m infected with another 24 Meriones unguiculatus were divided into three groups, were attacked and sensitized, the establishment of allergic reaction model. After a definitive injection of allergens, observe the symptoms 60min and then determine IgE levels. The result is IgE level with E m gerbils infected with the passage of time increased, the attack before reaching the peak, after 60min significantly decreased. The highest incidence of allergic reactions was 100%, the lowest was 62.5%, the incidence of anaphylactic shock was 12.5%. Allergic model of typical symptoms, the results are reliable and can be applied to hydatid disease caused by anti-allergic shock series of experimental studies. Changes in IgE levels play an important role in the occurrence and development of anaphylactic shock induced by hydatid disease