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目的探讨阿昔洛韦联合外用重组人干扰素α-2b喷雾剂治疗带状疱疹的临床疗效及安全性。方法选择2015年2月至10月邯郸市第一医院100例带状疱疹患者,其中男性44例,女性56例;年龄16~82岁,平均年龄51.11岁。随机分为观察组和对照组,每组50例。对照组给予阿昔洛韦片0.2 g,口服4次/天,10 d为1个疗程,给予维生素B1200 mg,口服3次/天,共治疗20 d;观察组在此基础上加用重组人干扰素α-2b喷雾剂,每处皮损2喷,4次/天,共治疗20 d。应用药物治疗20 d后,观察临床疗效及其水疱消退、脱痂及疼痛缓解时间。结果观察组临床疗效显著优于对照组(96%vs 76%;P<0.01),两组疼痛缓解时间、水疱消退时间及脱痂时间比较[(12.40±4.10)d、(10.70±1.80)d、(13.20±4.20)d vs(14.90±4.30)d、(12.30±2.90)d、(15.90±4.40)d],观察组明显缩短(P<0.01)。无明显不适、肝肾损伤等不良反应发生。结论阿昔洛韦联合外用重组人干扰素α-2b喷雾剂治疗带状疱疹可明显缩短病程,临床疗效明确,应用简单,适宜推广。
Objective To investigate the clinical efficacy and safety of acyclovir plus topical recombinant human interferon α-2b spray in the treatment of shingles. Methods From February to October 2015, 100 cases of herpes zoster were admitted to the First Hospital of Handan City, including 44 males and 56 females, aged from 16 to 82 years with a mean age of 51.11 years. Randomly divided into observation group and control group, 50 cases in each group. The control group was given acyclovir 0.2 g, orally 4 times a day, 10 d for a course of treatment, given vitamin B1200 mg, orally 3 times / day for a total of 20 days; the observation group on the basis of the use of recombinant human Interferon α-2b spray, each spray 2 lesions, 4 times / day, a total of 20 d. After 20 days of drug treatment, the curative effect of the drug and the elimination of blisters, scab off and pain relief time were observed. Results The clinical curative effect of the observation group was significantly better than that of the control group (96% vs 76%; P <0.01). The pain relief time, the blister subsidence time and the time of scabbing were compared between the two groups [(12.40 ± 4.10) d and (10.70 ± 1.80) d , (13.20 ± 4.20) d vs (14.90 ± 4.30) d, (12.30 ± 2.90) d, (15.90 ± 4.40) d respectively. The observation group was significantly shorter (P <0.01). No obvious discomfort, liver and kidney damage and other adverse reactions. Conclusion The combination of aciclovir and topical rhIFN-α-2b spray can shorten the course of the disease obviously. The clinical effect is clear, and the application is simple and suitable for promotion.