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目的探讨性激素在男性胃癌发病中的意义。方法采用放射免疫分析法检测32例男性胃癌患者及30例同年龄男性健康体检者血清中的雌二醇(ESTRADIOL,E2)、睾酮(Testosterone,T)及泌乳素(Prolactin,PRL)水平。结果胃癌组血清E2、T、PRL分别为41.81±5.53pg/ml、813.36±47.57ng/dl、14.35±1.52ng/ml,胃癌组血清E2、T明显低于对照组(P<0.05),而PRL明显高于对照组(P<0.05)。结论男性胃癌的发生可能与性激素代谢失衡有一定的关系。
Objective To investigate the significance of sex hormones in the pathogenesis of gastric cancer in men. Methods Serum estradiol (E2), testosterone (T) and prolactin (PRL) were detected by radioimmunoassay in 32 patients with gastric cancer and 30 healthy men at the same age. Results Serum E2, T and PRL in gastric cancer group were 41.81 ± 5.53pg / ml, 813.36 ± 47.57ng / dl and 14.35 ± 1.52ng / ml, respectively. Serum E2 and T levels in gastric cancer group were significantly lower than those in control group (P <0.05) PRL was significantly higher than the control group (P <0.05). Conclusion The occurrence of gastric cancer in men may be related to the imbalance of sex hormone metabolism.