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病毒性肝炎是一个影响全世界人们身体健康的重要公共卫生问题。全球约有3.5亿乙型肝炎(HBV)慢性感染者,1.5亿丙型肝炎(HCV)慢性感染者。我国是病毒性肝炎的高流行区,HBV慢性感染者约有1.2亿。乙型和丙型肝炎病毒持续感染和慢性化进展是肝硬化和肝细胞癌的重要高危因素。肝癌是最常见的恶性肿瘤之一,其发病率较高且病情进展快,致死率在我国恶性肿瘤中高居第三位。肝癌具有高复杂性和高度异质性的特点,其发生机制比较复杂。
Viral hepatitis is an important public health problem that affects the health of people all over the world. There are about 350 million people with chronic hepatitis B (HBV) infection and 150 million people with chronic hepatitis C (HCV) infection worldwide. China is a high endemic area of viral hepatitis, HBV chronic infection about 120 million. Persistent infection and chronic progression of Hepatitis B and C are important risk factors for cirrhosis and hepatocellular carcinoma. Liver cancer is one of the most common malignant tumors, its incidence is high and the disease progresses rapidly. The death rate is the third highest among malignant tumors in our country. Liver cancer has the characteristics of high complexity and high heterogeneity, and its mechanism is complicated.