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1例35岁男性患者,因慢性丙型肝炎给予聚乙二醇干扰素α-2b 200万U肌内注射,1次/周。4个月后患者出现幻听、妄想,性格有轻微改变。随后症状逐渐加重,1周后出现被害妄想、思维散漫、情感不协调、易激惹和自知力障碍。遂停用该药,并给予奥氮平对症治疗。治疗1周症状明显好转,治疗2周出院。出院后继续应用奥氮平治疗1周,随后自行停药,随访半年未再出现上述精神症状。
One 35-year-old male patient received peginterferon alfa-2b 200 million U intramuscularly for 1 week / week due to chronic hepatitis C. 4 months after the patient appeared auditory hallucinations, delusions, minor changes in character. Subsequent symptoms gradually aggravated, 1 week after the victim delusion, loose thinking, emotional dissonance, irritability and intellectual disabilities. Then stop the drug, and give olanzapine symptomatic treatment. 1 week treatment symptoms significantly improved treatment of 2 weeks discharged. Olanzapine continued to be treated for 1 week after discharge and then discontinued on its own. The above psychiatric symptoms did not recur after 6 months of follow-up.