论文部分内容阅读
有机溶剂对雌(女)性生殖毒性产生的影响近年来引起人们高度重视。其危害主要包括月经周期紊乱、激素水平改变、妊娠过程及结局的影响、胚胎毒性和致畸作用等,毒作用机制可能通过与靶分子结合、直接抑制激素的合成、与小分子物质的氧化作用而直接发挥作用,影响神经、免疫等机体其他系统而发挥内分泌干扰作用等。本文综述了这些方面的研究现状与进展。
In recent years, the influence of organic solvents on female reproductive toxicity has drawn great attention. Its harmfulness mainly includes the disorder of menstrual cycle, the change of hormone level, the influence of pregnancy process and outcome, embryotoxicity and teratogenicity, etc. The toxic mechanism may directly inhibit the synthesis of hormones and the oxidation of small molecules by binding to target molecules And play a direct role in affecting the nervous, immune and other body systems to play an endocrine disrupting effect. This article summarizes the research status and progress in these aspects.