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目的探讨四磨汤口服液对脾虚便秘的疗效机制。方法用番泻叶水煎液灌胃制作脾虚模型,然后停用番泻叶,通过控制饮食和饮水制备脾虚便型。治疗组给予四磨汤口服液灌胃,模型组和正常组均给予无菌水灌胃。结果在体重影响方面,治疗组、模型组和正常组三组对比,治疗组有明显改善,差异具有统计学意义(P<0.05);在免疫功能方面,三组对比,治疗组有极显著改善,差异具有统计学意义(P<0.01)。结论四磨汤口服液能增强脾虚便秘小鼠的非特异性免疫功能。
Objective To investigate the therapeutic effect of Siweitang Oral Liquid on constipation of spleen. Methods The model of spleen deficiency was made by gavage of senna decoction and then the senna was stopped, and the spleen deficiency type was prepared by controlling diet and drinking water. The treatment group was given oral Sirao Tang gavage, the model group and the normal group were given sterile water gavage. Results Compared with the control group, the treatment group, the model group and the normal group showed significant improvement in body weight, the difference was statistically significant (P <0.05); in the immune function, the three groups were significantly improved compared with the treatment group , The difference was statistically significant (P <0.01). Conclusion Si Mo Tang oral liquid can enhance the non-specific immune function of spleen-deficient mice.