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目的:探讨益肾化痰方联合二甲双胍对多囊卵巢综合征合并胰岛素抵抗的临床疗效。方法:纳入符合观察标准的多囊卵巢综合征合并胰岛素抵抗患者90例,随机分为中药组、西药组、中西药组,每组各30例。中药组予益肾化痰方,西药组予二甲双胍,中西药组予益肾化痰方加二甲双胍,各组疗程均为3个月。观察治疗前后临床症状、妊娠情况,检测糖代谢指标与性激素水平的改善情况。结果:中西药组在基础体温(BBT)及月经改善方面的临床疗效明显优于单纯中药组及西药组(P<0.05)。中西药组与西药组可显著降低胰岛素(FINS)、稳态胰岛素评价指数(HOMA-IR)(P<0.01),而中药组无明显影响(P>0.05);中西药组与中药组能明显降低血清黄体生成素(LH)、睾酮(T)水平(P<0.01),而西药组仅可降低T水平(P<0.05)。结论:益肾化痰方联合二甲双胍可明显改善多囊卵巢综合征并胰岛素抵抗患者的临床症状和内分泌及糖代谢,恢复月经周期。
Objective: To investigate the clinical efficacy of Yishen Huatan Decoction combined with metformin in patients with polycystic ovary syndrome complicated with insulin resistance. Methods: Ninety patients with polycystic ovary syndrome and insulin resistance were enrolled in the study. They were randomly divided into TCM group, western medicine group and western medicine group, with 30 cases in each group. Chinese medicine group Yishen Huatan Fang, western medicine group metformin, Chinese medicine and western medicine group to Yishen Huatan side plus metformin, each course of treatment were 3 months. Observed before and after treatment of clinical symptoms, pregnancy, glucose metabolism indicators and sex hormone levels improved. Results: The clinical curative effect of traditional Chinese medicine and Western medicine on basal body temperature (BBT) and menstrual improvement was significantly better than those of simple Chinese medicine group and western medicine group (P <0.05). The levels of insulin and homeostasis index (HOMA-IR) in Chinese medicine group and western medicine group were significantly decreased (P <0.01), but not in Chinese medicine group (P> 0.05) (P <0.01), while the western medicine group only reduced the level of T (P <0.05). Conclusion: Yishen Huatan Decoction combined with metformin can significantly improve the clinical symptoms and endocrine and glucose metabolism in patients with polycystic ovary syndrome and insulin resistance and restore the menstrual cycle.