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目的 了解冻干风疹减毒活疫苗的免疫持久性。方法 在湖南省浏阳市 8月~ 6岁风疹血清HI抗体阴性儿童中 ,进行了连续 5年的冻干风疹减毒活疫苗免疫后血清学效果研究。结果 免疫 1个月后风疹HI抗体的阳转率为 97 2 % ,抗体几何平均滴度倒数 (GMT)为 15 7 6。免后 1、2、3、4、5年风疹HI抗体阳性率仍维持较高水平 ,分别为 99 7% ,10 0 0 % ,98 3 % ,97 3 %和 95 5 % ;而HI抗体的GMT则出现显著性下降 ,分别为 141 2 ,113 3 ,67 4,3 7 3和 3 1 2。在连续观察的 5年当中 ,共有 3 2名观察对象的HI抗体 (≤ 1∶3 2 )出现 4倍增长 ,获得隐性感染 ,共有 17名观察对象的HI抗体阴转 ,5年累积阴转率为 9 2 4%。结论 国产冻干风疹减毒活疫苗免疫持久性效果满意
Objective To understand the immune persistence of freeze-dried rubella live attenuated vaccine. Methods The serological effects of live attenuated freeze-dried rubella vaccine after 5 years of continuous immunization in children with measles serum HI antibody from August to 6 years old in Liuyang, Hunan Province were studied. Results After 1 month of immunization, the positive rate of rubella HI antibody was 97.2% and the geometric mean antibody titer (GMT) was 15 7 6. The positive rates of rubella HI antibody remained high at 1, 2, 3, 4 and 5 years after immunization (99.7%, 100%, 98 3%, 97 3% and 95 5% respectively) GMT showed a significant decline, respectively, 141 2, 113 3, 67 4, 373 and 3 1 2. During the 5 years of continuous observation, a total of 32 observed HI antibodies (≤ 1: 3 2) showed a 4-fold increase, resulting in a latent infection. A total of 17 subjects were negative for HI antibody and had a 5-year cumulative negative conversion The rate was 92.4%. Conclusion The results showed that the live-cured freeze-dried rubella live vaccine was satisfactory