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历史上,人类长期蒙受各种传染病的困扰,其中的烈性传染病,如黄热病、鼠疫、霍乱以及流感等,以其大面积的迅速传播和极高的死亡率直接威胁到人类的健康和生存。千百年来,可怕的免疫疾病迫使人类与之进行着不懈的斗争。这些病原体在哺乳动物体内形成慢性感染,具有逃避宿主免疫反应的能力。“聪明”的细菌是如何逃脱哺乳动物免疫系统进攻的呢?这一问题一直得不到明确答案。中国科学院健康科学研究所戈宝学组经过长期对宿主与病原体相互作用的研究,发现了一个细菌逃避宿主免疫反应的新机制。他们发现了细菌中含ITIM(免疫酪氨酸抑制基序)的蛋白对宿主TLR信号通路的抑制作用。该研究所发现的机制很可能是病原体逃避宿主免疫反应的一个普遍机制,为病原体蛋白在免疫系统中的致病机理提供了新的分子基础,更为开发感染性疾病新的治疗方法提供了重要理论依据。
Historically, mankind has been plagued by various infectious diseases for a long time. Among them, severe infectious diseases such as yellow fever, plague, cholera and flu have posed a direct threat to human health due to its rapid spread and high mortality rates And survive. For thousands of years, terrible immune diseases have forced humankind to wage an unrelenting struggle against it. These pathogens form a chronic infection in mammals and have the ability to evade host immune responses. How can the “smart” bacteria escape the attack of the mammalian immune system? There is no clear answer to this question. After a long period of research on the interaction between host and pathogen, Gebao group of Institute of Health Sciences, Chinese Academy of Sciences found a new mechanism for bacteria to evade the host immune response. They found that bacteria contain ITIM (immunosytisine -inhibiting motif) protein on the host TLR signaling pathway inhibition. The mechanisms discovered by this study are likely to be a common mechanism by which pathogens evade the immune response of the host and provide a new molecular basis for the pathogenesis of pathogenic proteins in the immune system and provide further insight into the development of new therapeutic approaches to infectious diseases Theoretical basis.