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大白鼠接受1100倫琴X綫全身照射。照射後1—8晝夜時靜脈內注入標記(I~(131)及S~(35)血漿蛋白。注入後5、15、30分鐘及30分鐘後到360分鐘每隔半小時取血,2或6小時後殺死動物取其內臟,製備血液及組織標本,测其放射性。藉以觀察標記血漿白血液排出之速度及其在體內各器官中之分佈。實驗結果發現,照射後標記血漿蛋白自循環血液中排出加速,这一加速尤以4—6晝夜時为著。此時,標記血漿蛋白注入後30—120分鐘间,對照鼠的半排出時達照射鼠的1.44—2.7倍。照射後標記血漿蛋白在各器官中之含量亦見增多,這一增多尤以肺、腸、心、胃等器官为主。作者認为這些变化表明,致死量X綫全身照射引起了大白鼠血管對標記血漿蛋白通透性的增高。
Rats received 1,100 roentgen X-ray whole body irradiation. After intravenous injection of labeled (I ~ (131) and S ~ (35) plasma proteins 1-8 days and nights after irradiation, blood was collected every 5 to 30 minutes and 30 minutes to 360 minutes after half an hour, 2 or After 6 hours, the animals were sacrificed and their internal organs were taken out to prepare blood and tissue samples for measuring the radioactivity, thereby observing the rate of white blood plasma marking and its distribution in various organs of the body. The experimental results showed that the labeled plasma proteins were self-circulated The acceleration of blood excretion, the acceleration is especially 4-6 days at this time, marking the plasma protein injection 30-120 minutes after the control mice half discharge up to 1.44-2.7 times the irradiated rats. The content of plasma protein in various organs also see increased, especially in lung, intestine, heart, stomach and other organs.The author believes that these changes indicate that the lethal dose of X-ray caused by systemic blood vessels in the marked plasma Increased protein permeability.