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大量细胞遗传学研究已清楚地表明,许多非随机性染色体畸变与特定的良性和恶性软组织肿瘤的发生发展有关,对特定软组织肿瘤中特异性的染色体易位、缺失及其它畸变的认识有力地推动了肉瘤分子遗传学研究的快速发展。目前已很清楚,除癌基因和肿瘤抑制基因点突变外,染色体易位和丢失所致的癌基因或肿瘤抑制基因的重排和丢失也是肉瘤发生的重要分子机
A large number of cytogenetic studies have clearly demonstrated that many non-random chromosomal aberrations are associated with the development of specific benign and malignant soft-tissue tumors, and strongly promote the recognition of specific chromosomal translocations, deletions, and other aberrations in specific soft tissue tumors. The rapid development of molecular genetic studies of sarcoma. It is now clear that in addition to point mutations in oncogenes and tumor suppressor genes, the rearrangement and loss of oncogenes or tumor suppressor genes caused by chromosome translocations and loss are also important molecular mechanisms for sarcoma development.