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Tigemonam是一个对革蓝氏阴性细菌有强大抗菌作用的口服单环β-内酰胺抗生素.本文观察了本品对动物药代动力学,小鼠全身感染、泌尿道感染和大鼠肺部感染等的保护作用,并与其他抗生素进行了对比.结果表明,小鼠口服50mg/kg,给药后10分钟血峰浓度(38μg/ml),其血峰浓度与头孢克罗、头孢氨苄和头孢羟氨苄等相似,但在2小时,本品血浓度明显高于上述对照药.狗口服25mg/kg的达峰时间为1小时,其血峰浓度与小鼠相似.其静脉和口服给药的AUC分别为158.3μg·hr/ml和133.1μg·hr/ml,两者比例为84.1%,本品两途径给
Tigemonam is an oral monocyclic β-lactam antibiotic that has a strong antibacterial activity against Gram-negative bacteria.In this paper, we observed the effects of this product on animal pharmacokinetics, systemic infection in mice, urinary tract infections and rat lung infections , And compared with other antibiotics.The results showed that when the mice were orally administered with 50 mg / kg orally, the peak plasma concentration was 38 μg / ml at 10 min after administration, and the peak plasma concentrations were similar to those of cefaclor, cephalexin and cefotiam Ampicillin and other similar, but at 2 hours, the product was significantly higher than the blood concentration of the control drug.Park oral 25mg / kg peak time of 1 hour, the peak blood concentration and mice similar to its intravenous and oral administration of AUC Respectively 158.3μg · hr / ml and 133.1μg · hr / ml, the ratio between the two was 84.1%, the product of two routes to