趋化因子是机体内一群能使白细胞发生趋化运动的小分子细胞因子,其中的C-C趋化因子主要趋化和激活单核细胞和某些T细胞亚群,与炎症和免疫反应密切相关。糖尿病大血管病变主要是指主动脉、冠状动脉、脑动脉、肾动脉等大血管动脉粥样硬化。本文主要探讨C-C趋化因子与糖尿病大血管病变发病机制的关系以及在糖尿病大血管病变诊断和治疗中的应用进展。 Chemokines are a group of small molecule cytokines that make leukocytes chemotactic. C-C chemokines mainly chemotactic and activate monocytes and certain T cell subsets, which are closely related to inflammation and immune responses. Diabetic macrovascular disease mainly refers to the aorta, coronary artery, cerebral artery, renal artery and other macrovascular atherosclerosis. This article mainly discusses the relationship between the C-C chemokines and the pathogenesis of diabetic macroangiopathy and its application in the diagnosis and treatment of diabetic macroangiopathy.