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目的探讨5-HT2A受体基因T102C多态性与ADHD的关联,为相关疾病的病因学研究提供参考。方法以包头市某小学974名6~14岁学生为研究对象,应用PCR-限制性片段长度多态性(PCR-RFLP)方法检测5-HT2A受体基因T102C多态性,采用病例对照研究方法分析5-HT2A受体基因T102C多态性对ADHD的影响。结果 5-HT2A受体基因T102C的基因型频率在ADHD组与对照组儿童间差异有统计学意义(χ2=5.28,P=0.02),TT基因型是ADHD的保护因素(OR=0.56,P<0.05),TC/CC基因型是ADHD的危险因素(OR=1.26,P<0.05)。结论 5-HT2A受体基因T102C多态性与ADHD的发生有关。
Objective To investigate the association between polymorphism of 5-HT2A receptor gene T102C and ADHD and to provide references for the etiology of related diseases. Methods A total of 974 students from 6 to 14 years old from a primary school in Baotou City were enrolled in this study. Polymorphism of 5-HT2A receptor gene T102C was detected by PCR-restriction fragment length polymorphism (PCR-RFLP). A case-control study Analysis of 5-HT2A receptor gene T102C polymorphism on ADHD. Results The genotype frequency of 5-HT2A receptor gene T102C was significantly different between ADHD group and control group (χ2 = 5.28, P = 0.02). TT genotype was the protective factor of ADHD (OR = 0.56, P < 0.05). TC / CC genotype was a risk factor for ADHD (OR = 1.26, P <0.05). Conclusion The polymorphism of 5-HT2A receptor gene T102C is associated with the development of ADHD.