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支气管哮喘是儿科常见病,严重危害儿童身体健康。过去以β肾上腺素能受体兴奋剂和茶碱类气管扩张剂治疗为主,目前随着药理学的不断发展,临床上应用一些老药治疗支气管哮喘,收到了比较满意的效果。现结合我们应用体会,综述如下: 1.红霉素 有报道用红霉素0.2g,口服每日3次,连续服用2个月、治疗支气管哮喘8例,6例治愈或缓解,总有效率75％。其机理为:(1)红霉素有拟类固醇作用。(2)降低细胞色素P_(450)复合物的活性。(3)抑制体内茶碱类物质的消除。该药治疗支气管哮喘合并感染效果尤佳,胃炎、胃溃疡患者忌用。
Bronchial asthma is a common pediatric disease, seriously endangering children’s health. In the past to beta adrenergic receptor agonists and theophylline type of tracheal expander therapy based, with the continuous development of pharmacology, the clinical application of some old drugs in the treatment of bronchial asthma, received more satisfactory results. Now combined with our application experience, are summarized as follows: 1. Erythromycin has been reported erythromycin 0.2g, 3 times daily oral administration for 2 months, the treatment of bronchial asthma in 8 cases, 6 cases of cure or remission, the total effective rate 75%. The mechanism is: (1) erythromycin has a quasi-steroid effect. (2) Reduce the activity of the cytochrome P_ (450) complex. (3) inhibit the elimination of theophylline substances in the body. The drug treatment of bronchial asthma combined infection is particularly effective, gastritis, gastric ulcer patients hanged.