目的　研究原发性高血压患者ACE基因多态性分布与卡托普利疗效的相关性。方法　 133名原发性高血压患者按ACE基因多态性的II ,ID与DD型三种 ,同时服用卡托普利 2 5mgbid ,服药前后作动态血压监测 ,以观察在各种不同ACE基因多态性间的区别。结果　ID型患者在 2 4小时收缩压 ,白天收缩压及夜间收缩压的降低程度均较其它型为明显 (P <0 0 5 )。结论 :转换酶抑制剂的作用可能与ACE的基因类型有关 Objective To investigate the relationship between ACE gene polymorphism and the efficacy of captopril in patients with essential hypertension. Methods 133 patients with essential hypertension according to ACE gene polymorphism II, ID and DD type three, taking captopril 25mgbid, taking medication before and after ambulatory blood pressure monitoring to observe in a variety of different ACE gene Differences between the states. Results The systolic blood pressure, daytime systolic pressure and nocturnal systolic blood pressure were significantly decreased in ID patients than in other patients (P <0.05). CONCLUSIONS: The role of ACE inhibitors may be related to ACE genotypes