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目的:了解坊子区0～14岁儿童乙型肝炎(乙肝)病毒表面抗原(HBsAg)携带现状,掌握乙肝表面抗原在儿童中的感染水平,为制定乙肝防控措施提供科学理论依据。方法:采用分层随机抽样坊子区0～14岁儿童,采集每名调查对象静脉血3～5ml,分离血清,用酶联免疫吸附实验(ELISA)进行HBsAg检测。结果:共检测2966名儿童,检出HBsAg37例,阳性率1.24%;随着年龄增长,HBsAg阳性率逐渐升高,差异统计学意义(p<0.01);有免疫史儿童的HBsAg阳性率(0.49%)低于无免疫史和免疫史不详儿童(3.65%)(p<0.01);城镇儿童HBsAg阳性率(0.89%)低于农村儿童(1.44%)(p<0.05)。结论:坊子区0～14岁儿童HBsAg携带率较低。今后应加强对无免疫史或免疫史不详儿童的乙肝疫苗补种工作。
Objective: To understand the status of hepatitis B virus (HBsAg) carrier in 0 ~ 14 years old children in Fangzi district and to know the infection level of hepatitis B surface antigen in children so as to provide a scientific basis for the development of hepatitis B prevention and control measures. Methods: Stratified random sampling was conducted in children from 0 to 14 years old in Fangzi District. Blood samples were collected from 3 to 5ml of venous blood of each subject. Serum samples were collected for serum HBsAg detection by enzyme-linked immunosorbent assay (ELISA). Results: A total of 2966 children were detected and 37 cases of HBsAg were detected, the positive rate was 1.24%. With the increase of age, the positive rate of HBsAg gradually increased (p <0.01), and the positive rate of HBsAg %) Was lower than that in children without history of immunization and history of immunization (3.65%) (p <0.01). The positive rate of HBsAg in urban children was 0.89% lower than that in rural children (1.44%) (p <0.05). Conclusion: The incidence of HBsAg in children aged 0-14 years in Fangzi district is low. In the future, vaccination of hepatitis B vaccine for children with no history of immunization or immunization should be strengthened.