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目的:研究前列宁栓的抗炎、镇痛作用。方法:采用二甲苯所致小鼠耳廓肿胀实验、角叉菜胶致大鼠足跖肿实验、大鼠棉球肉芽肿的影响实验、小鼠腹腔毛细血管通透性实验,细菌性(大肠杆菌)前列腺炎的抗炎作用。采用醋酸致小鼠扭体反应实验和小鼠热板法实验观察了前列宁栓的镇痛作用。结果:前列宁栓可明显抑制二甲苯所致的小鼠耳廓炎症;在多数时间降低角叉菜胶致大鼠足跖肿胀;明显抑制大鼠棉球肉芽肿的生成;明显降低小鼠腹腔毛细血管通透性;明显抑制大鼠细菌性前列腺炎;明显降低醋酸致小鼠扭体反应数;明显升高小鼠痛阈值。结论:前列宁栓具有明显的抗炎、镇痛作用。
Objective: To study the anti-inflammatory and analgesic effects of Qianliening suppository. Methods: The auricle swelling induced by xylene in mice, carrageenan-induced rat’s plantar swelling test, cotton granuloma in rats, peritoneal capillary permeability test in mice, bacterial Bacillus) Prostatitis anti-inflammatory effect. Analgesic effect of Qianliening suppository was observed by writhing reaction induced by acetic acid and by hot plate method in mice. Results: Qianliening suppository can significantly inhibit the auricle inflammation caused by xylene in mice; reduce carrageenin-induced paw edema in rats most of the time; significantly inhibit the formation of cotton ball granuloma; significantly reduce the abdominal cavity of mice Capillary permeability; significantly inhibit bacterial prostatitis in rats; significantly reduce the number of writhing reactions induced by acetic acid; significantly increased the pain threshold in mice. Conclusion: Qianliening suppository has obvious anti-inflammatory and analgesic effects.