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目的:探讨乙酰肝素酶(HPA)在鼻咽癌组织中的表达及临床意义。方法:运用免疫组织化学技术检测HPA在70例鼻咽癌和10例鼻咽正常组织中的表达情况,并结合鼻咽癌临床分期、颈淋巴结转移率、复发及转移率、5年生存率等临床病理特征进行分析。结果:鼻咽正常组织中无HPA阳性表达,鼻咽癌组织中HPA阳性表达率为52.9%(37/70)。鼻咽癌临床各期的HPA阳性表达率分别为:Ⅰ期30.0%(6/20),Ⅱ期45.8%(11/24),Ⅲ期70.6%(12/17),Ⅳ期88.9%(8/9)。有、无淋巴结转移组HPA阳性表达率分别为67.4%(31/46)和25.0%(6/24)。HPA阳性、阴性表达者的复发及转移率分别为48.6%(18/37)和15.2%(5/33),5年生存率分别为24.3%(9/37)和78.8%(26/33)。HPA阳性表达与鼻咽癌临床分期、颈淋巴结转移率、复发及转移率、5年生存率等临床病理特征有关(P<0.01)。结论:HPA表达与鼻咽癌的侵袭、转移及预后有关,为抗鼻咽癌治疗提供一个新的可能靶点。
Objective: To investigate the expression of heparanase (HPA) in nasopharyngeal carcinoma and its clinical significance. Methods: Immunohistochemistry was used to detect the expression of HPA in 70 cases of nasopharyngeal carcinoma and 10 cases of nasopharyngeal normal tissues. Combined with the clinical stage of nasopharyngeal carcinoma, cervical lymph node metastasis, recurrence and metastasis rate, 5-year survival rate Clinicopathological features were analyzed. Results: There was no positive expression of HPA in normal nasopharyngeal tissues, and the positive expression rate of HPA in nasopharyngeal carcinoma was 52.9% (37/70). The positive rates of HPA expression in nasopharyngeal carcinoma were 30.0% (6/20) in stage Ⅰ, 45.8% (11/24) in stage Ⅱ, 70.6% (12/17) in stage Ⅲ and 88.9% /9). The positive expression rates of HPA in those with and without lymph node metastasis were 67.4% (31/46) and 25.0% (6/24), respectively. The recurrence and metastasis rates were 48.6% (18/37) and 15.2% (5/33) in HPA positive and negative patients, respectively. The 5-year survival rates were 24.3% (9/37) and 78.8% (26/33) . The positive expression of HPA was related to clinicopathological features of NPC including clinical stage, cervical lymph node metastasis, recurrence and metastasis, 5-year survival rate (P <0.01). Conclusion: The expression of HPA is related to the invasion, metastasis and prognosis of nasopharyngeal carcinoma, which may provide a new possible target for the treatment of.