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1研究背景2012年全球约有150万人死于糖尿病,其中80%以上的糖尿病相关死亡发生于中低收入国家。此外,2010年约有4700万人因糖尿病而残疾(失明、截肢、肾功能衰竭、心血管事件)。调整生活方式和应用降糖药治疗是预防和延缓糖尿病相关并发症的主流。已有很多种类的降糖药经批准用于治疗2型糖尿病,包括二甲双胍、胰岛素、磺脲类药物、噻唑烷二酮类药物、二肽基肽酶-4(dipeptidyl
1 Research Background In 2012, about 1.5 million people died of diabetes in the world, of which more than 80% of diabetes-related deaths occurred in low and middle-income countries. In addition, about 47 million people were disabled due to diabetes in 2010 (blindness, amputation, renal failure, cardiovascular events). Adjusting lifestyle and applying hypoglycemic agents are the mainstay in preventing and delaying the complications associated with diabetes. A number of classes of hypoglycemic agents have been approved for the treatment of type 2 diabetes including metformin, insulin, sulfonylureas, thiazolidinediones, dipeptidyl