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目的探讨Caspase-3对葡萄胎患者再次生育的指导意义。方法选择34例Caspase-3高表达的非恶变葡萄胎患者,对生育情况及妊娠结局随访2a,根据清宫术与再次妊娠时间间隔分为3组:甲组为清宫术后6个月内妊娠,乙组为清宫术后6个月～1a内妊娠,丙组为清宫术后1a后妊娠。结果 34例非恶变葡萄胎患者中26例未严格避孕,其中24例受孕。甲组、乙组、丙组病理妊娠率分别为40.00%、0.00%、7.69%。结论葡萄胎患者中Caspase-3高表达者恶变率低,清宫术后6个月病理妊娠率明显降低,可考虑妊娠。
Objective To investigate the guiding significance of Caspase-3 on the fertility of patients with hydatidiform mole again. Methods 34 cases of nonmalignant hydatidiform mole with high expression of Caspase-3 were selected and their reproductive status and pregnancy outcome were followed up2a. The patients were divided into 3 groups according to the time between re-pregnancy and the curettage: group A was pregnancy within 6 months after operation, Group B for the Qing after 6 months ~ 1a pregnancy, group C after the curettage after 1a pregnancy. Results Of the 34 non-malignant hydatidiform mole patients, 26 were not strictly contracted and 24 were pregnant. Group A, Group B, Group C pathological pregnancy rates were 40.00%, 0.00%, 7.69%. Conclusions The positive rate of Caspase-3 in hydatidiform mole was low, and the pregnancy rate was significantly lower at 6 months after operation.